Purpose: The purpose of the present investigation was to examine to what extent precision data from 3-dimensional planning software for oral implants can be transferred to the operative field by means of a drilling template, containing high-precision drilling sleeves, fitted on the jawbone. It was investigated whether this procedure would allow advance preparation of a fixed definitive prosthesis that could be placed at the completion of surgery. Materials and Methods: This procedure was experimentally carried out in 2 cadavers and later in 8 consecutive human patients. Results: The results indicated a nearly perfect match between the positions and axes of the placed implants and those planned. Discussion: This procedure permitted the placement of a definitive fixed prosthesis with limited freedom of space between the abutments and the metallic cylinders incorporated into the prosthesis. Conclusion: These encouraging results of the Leuven information technology-based oral rehabilitation by means of implants (LITORIM) are presently being further investigated at the clinical level.