Reinforcement of acrylic denture base resin with high-performance polyethylene fiber in woven form produced a substantial improvement of stiffness and impact strength, as well as reducing the sensitivity of the material to notches that mimic anatomic features. The mechanical properties of the new systems were not affected by water immersion. Reinforced complete maxillary and mandibular dentures having good appearance and satisfactory fiber/resin integration were achieved using conventional laboratory techniques. These prostheses are undergoing clinical trials with encouraging results.