PURPOSE: This is a 2-year report from an ongoing prospective 5-year multicenter study. The aim of the study was to evaluate the short- and long-term clinical function of CerAdapt ceramic abutments supporting short-span fixed partial dentures (FPD). MATERIALS AND METHODS: Initially, 105 Brånemark System implants were placed in a total of 32 patients at 3 different clinics. After initial healing 103 implants remained. For the support of 36 FPDs, 53 ceramic and 50 titanium abutments were connected, 19 on ceramic and 17 on titanium abutments. RESULTS: All patients remained in the study after 2 years. There was a cumulative survival rate of 97.1% for implants and a cumulative success rate of 97.2% for FPDs (94.7% for ceramic and 100% for titanium abutment-supported FPDs). One of 53 ceramic but none of 50 titanium abutments failed, giving a cumulative success rate of 98.1% and 100%, respectively, for the abutments. Soft tissue around abutments and adjacent teeth appeared healthy. More crown margins were placed submucosally at titanium (31%) than at ceramic (14%) abutments, and the level of the periimplant mucosa was relatively stable in relation to the abutment/crown. No differences were seen between ceramic and titanium abutments regarding bleeding of the periimplant mucosa. There was a minimal marginal bone loss recorded after 1 year, which was slightly more at titanium (0.4 mm) than at ceramic (0.2 mm) abutments. All patients and dentists were satisfied with the achieved esthetic result and no FPD was remade because of compromised esthetics. CONCLUSION: So far the ceramic abutments have worked very well and the 2-year results have been very encouraging for CerAdapt abutments supporting short-span FPDs. However, ceramic materials tend to undergo static fatigue, and it is therefore important to wait for the 5-year results before making any more definite statement about the long-term prognosis for CerAdapt abutments.