Purpose: This retrospective longitudinal study evaluated the success of implant prosthetic rehabilitation with the Frialit-2 implant system. Materials and Methods: The study was performed with 504 patients, from two treatment centers, who had received a total of 1,554 implants between May 1990 and May 2001. The data of these patients, who received the implants in various regions and for various indications, were analyzed with respect to clinical, topographic, and radiographic parameters. The mean observation period was 6.2 years, with a maximum of 134 months. Results: A survival rate of 94.8% was found for all implants. The implant survival rate of 92.6% in the maxilla remained constant after 68 months of observation. In the mandible, the implant survival rate of 96.7% showed no changes after 76 months. Kaplan-Meier analysis identified jaw, occurrence of postoperative complications, and region as statistically significant factors influencing implant survival. Multivariate Cox regression showed that gender, occurrence of postoperative complications, and jaw were factors that increased the risk of implant loss. Statistically significant correlations were found between the incidence of implant loss and vertical bone loss adjacent to the implant at the time of second-stage surgery. Conclusion: Implant survival rate is influenced by implant site, gender, and occurrence of complications. On the whole, the Frialit-2 system proved successful in all areas of indication after long-term observation.