Purpose: The present report describes a relatively simple but effective prosthodontic treatment following removal of a moderately well differentiated osteogenic chondrosarcoma in the premaxillary region. Materials and Methods: Following removal of a rare tumor, a young man was treated with gold crowns on three molars and a metal-ceramic crown on a first premolar, with attachments in the areas facing the defect for esthetic reasons. A removable partial denture was retained by the attachments and conventional cast retentive circumferential clasps, including a hollow obturator filling the defect. Results: The restoration has served the patient for 16 years, seemingly without discomfort, and it has not required any maintenance. The patient has kept up with his oral hygiene, using conventional methods for the teeth and prosthesis, with periodic flushing with chlorhexidine solution. He has lived a normal family life and finished his university education. Conclusion: The problem-free use of the appliance can be at least partly explained by the patient taking oral hygiene measures seriously from the beginning. This report explains how relatively uncomplicated prosthodontic measures can enormously affect quality of life.