This in vitro study compared the effect of glazed and polished dental ceramic on the wear of human enamel. Five ceramics were tested under standard load after 150,000 and 300,000 simulated chewing cycles. Wear was determined from collected digital data and analyzed before and after loading. Statistical comparisons were analyzed. Polished ceramics produced less enamel wear. The amount of enamel wear for opposing IPS Empress ceramic was significantly higher (P .001) than wear provoked by the other ceramics. The enamel wear rate was higher at the first 150,000 cycles, and polishing increased ceramic roughness, except for the IPS Empress ceramic. Polishing of dental ceramics at the contact area produces less antagonistic enamel wear.