The aim of this report is to present a case with a 10-year follow-up of a single anterior tooth dental implant replacement with a xenogenous bone graft in a patient with a large bone defect associated with a cleft lip and palate. At 10 years postloading, the implant was healthy and wellintegrated. Although the implant restoration appeared slightly intruded due to growth and development at that time, the patient was happy with the esthetic result and refused corrections of the uneven occlusal plane.