Sjögren's syndrome, the unknown etiologic factors, is an autoimmune process that results in rheumatoid arthritis and causes dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia) because of the destruction of lacrimal and salivary gland. It is divided clinically two type which one is called primary Sjögren's syndrome (SS-1) represented by xerostomia and keratoconjunctivitis sicca, and seconder Sjögren's syndrome (SS-2) represented systemic connective tissue disease in addition to dry eyes and mouth. The peak age of onse is 50 years, and 90% of cases occur in women. The chief oral complaint is xerostomia, causes the eating, speaking lubrication, taste difficulties. Also there are a greater risk for dental caries, periodantal disease, and oral candidiasis. In this poster, we present a 23-year-old women had diagnosed Sjögren's syndrome,unknown type of syndrome. As a result of the biochemical and radyologic investigaments seconder Sjögren's syndrome, xerostomia, keratoconjunctivitis sicca and rheumatoid arthritis was diagnosed in ours clinic. The restoration of all caries teeth which were involved the endodontic treatment of lower santral teeth, the composit restoration with screw following the filling root canals and prothetic rehabilitation, the elevation of vertical dimention and fixed prothetic restoration were made and gave a flour tablets and oral hygein. Patient has been followed-up. Keywords: sjögren's syndrome, prothetic rehabilitation, autoimmune disease