An oily Calcium Hydroxide suspension has been shown to enhance healing of various types of bone defects. The aim of this study was to evaluate de effect of a combination of an oily Calcium Hydroxide suspension (Osteoinductal®, Osteoinductal GmbH, Muenchen, Germany) with α-TCP (BioBase® α -pore, Biovision GmbH, Ilmenau, Germany) vs. α -TCP alone in the treatment of one- and two-wall intrabony pockets. 12 patients with moderate to severe chronic periodontitis and displaying a total of 26 intrabony defects were included in the study. The intrabony defects were randomly treated with either α-TCP alone or with the combination of α-TCP and Osteoinductal®. The following parameters were evaluated at baseline and six months after surgery: probing depth (PD), gingival recession (GR) and clinical attachment level (CAL). Post surgical care included administration of antibiotics (Amoxycillin) 3x500mg daily for one week and 0.2% chlorhexidine rinses twice daily for two weeks. At six months after surgery the results revealed in the combination group a mean CAL change from 8.07±1.44 mm to 4.21±1.81 mm (p Keywords: periodontal regeneration, oily calcium hydroxide suspension, alpha-TCP