Introduction:This case report shows an interdisciplinary treatment approach in a 27 years old Patient with upper midline deviation, crowding in lower jaw and need for restoration in regio 2.4-2.5 as chief compliant. Materials and Methods:Midline deflection in upper jaw, aplasia 2.4 & 2.5, severe crowding in mandible and buccal non-occlusion of 3.5. The patient had a removable interim denture. She decided to undergo a comprehensive orthodontics-implantology therapy which consisted of extraction of 3 premolars and a dental implant for 2.4 after an intense consultation. Results:The upper midline deviation was corrected in 21 months using a fixed appliance and space for the dental implant regio 2.4 was created. The crown was fitted 4 months after the insertion of the implant. Vacuum formed retainer with occlusal adjustment in upper jaw and bonded lingual retainer in lower jaw were used to stabilize the result. Discussion:Extensive tooth movement can also be carried out in adult patient. A multidisciplinary treatment requires a good cooperation of several departments. Keywords: orthodontics, agenesis of tooth, dental implants, extraction