Objectives: To evaluate benefits of combined therapy in gingival recession coverage using collagen matrix together with platelet-rich plasma. Methods: Restoration of natural gum margin is one of the main goals in gingival recession coverage. Traumatic brushing, insufficient amount and width of keratinized gingiva and protrusion of teeth are among the most frequent causes of gingival recession. Microsurgery procedures such as autologous free mesenchymal grafts are used for coverage of gingival recession. However, some patients experience pain and discomfort of the donor site after the surgery. New methods are developed to avoid such complications. Results: Collagen Matrix (CM, Mucograft, Geistlich, Switzerland) was designed for gingival recession coverage and for augmentation of keratinized tissue around teeth and implants. CM can be trimmed using scissors and is packed in a sterile box. CM is ready for immediate use without any activation or preparation and is taken as a predictable alternative to free mesenchymal graft. In dry state the handling is almost similar to autologous tissue. CM might be sutured to allow tight adaptation to the root surface and to ensure complete immobility during healing. Platelet-Rich Plasma (PRP) is autologous peripheral blood derivate that contains high concentration of growth factors. Combined therapy using PRP with CM can lead to better clinical outcomes and diminish postoperative complications of the patient. Conclusions: Successful gingival recession coverage using combination of CM and PRP is presented. Within the limitation of small number of operated patients we can conclude that PRP improves the postoperative comfort and diminishes swelling of the wound in the early stage of healing. Randomized controlled trials are needed to prove the potential benefits of combined CM and PRP therapy. Keywords: gingival recession, collagen matrix, platelet-rich plasma