In a surgery first (SF) approach, no presurgical orthodontic treatment is carried out, and orthognathic surgery (OGS) is the first step in the correction of skeletal disharmonies. Once the OGS for the correction of skeletal problems is completed, post-surgical orthodontic treatment is required to correct transitional malocclusions with complex dental problems. Recently, in a move away from the use of fixed appliances in post-surgical orthodontic treatment in SF, a new option has been provided to support those patients who desire post-surgical orthodontic treatment with aesthetic and comfortable clear aligners. In this case report, a 24-year-old man with skeletal Class III malocclusion successfully underwent a SF approach followed by short-term fixed appliances, and aligner treatment for detailing and finishing. Keywords: aligners, Class III malocclusion, detailing and finishing, post-surgical orthodontics, skeletal anchorage, surgery first