Purpose: To test the cleaning efficacy of different manual toothbrushes in orthodontic patients in a single-blind randomised clinical trial. The brushes tested were selected based on previous in vitro tests. Materials and Methods: Thirty-five regular orthodontic patients with a minimum of six bonded brackets on the maxillary anterior teeth were randomly assigned to three experimental groups: staged (2-level) (Candida Parodin, 12 patients) and V-shaped (Oral-B Ortho, 12 patients) toothbrush head designs were compared in a two-phase study to planar control brushes (Paro M 43, 11 patients). First, all participants were advised to brush their teeth twice daily for 2 min for 3 weeks. Prior to the start and at the end of the study, the gingival index was assessed to evaluate the level of oral hygiene. Afterwards, cleaning efficacy was assessed planimetrically by disclosing the respective teeth after two days of not performing any oral hygiene measures. Results: Of the initial 35 participants, two did not attend after 3 weeks and had to be excluded. After 3 weeks, the control (5 out of 180 sites or -2.8% with GI ? 2) and staged groups (16 out of 216 sites or 7.5% with GI ? 2) showed minor improvement in the oral hygiene level. In contrast, the V-shaped group (29 out of 198 sites or 14.6 % with GI ? 2) showed a statistically significant improvement of the oral hygiene level. Planimetric evaluation, however, showed no superior cleaning efficacy of any of the tested head designs. Conclusions: The use of V-shaped and staged toothbrush head designs might be beneficial in patients with inadequate oral hygiene undergoing orthodontic treatment with a fixed appliance. Further large-scale investigations are, however, necessary to validate the presented results. Palabras clave: bracket, efficacy, orthodontic, RCT, toothbrush