Mandibular advancement devices (MADs) for the treatment of obstructive sleep apnea (OSA) have been part of contractual dental care since 2022 and are becoming more widespread in dental practices. Based on the corresponding specifications of the S1 guideline from 2021 of the Association of the Scientific Medical Societies in Germany (AWMF), the clinical steps required for this in collaboration with medical sleep medicine are explained on the basis of a case study. Non-adherence to positive pressure therapy has triggered a dental treatment cascade resulting in the successful treatment of OSA. Special attention is given to the assessment of the dental risk profile and the management of the potential side effects. MAD therapy in the context of dental sleep medicine consequently reinforces the integration of dentistry into general medicine.