Infections of endodontic origin rarely cause neural injury. This article presents a case of paraesthesia caused by endodontic infection of the left mandibular molar associated with large periradicular radiolucency. The sensory disturbance disappeared one week after chemo-mechanical preparation and intracanal dressing with a calcium hydroxide paste in camphorated paramonochlorophenol and glycerin. Complete healing of the periradicular tissues was radiographically observed after 24 months. Keywords: endodontic infection, inferior alveolar nerve, paraesthesia