Introduction: The aim of the present study was to examine the validity of the Child Perceptions Questionnaire (CPQ11-14) by exploring the association between oral health related quality of life (OHRQoL) with the overall well-being in a random population sample of 11- to 14-year-old children in Germany. Patients and Methods: 1589 children were drawn from a nation-wide sample considering the size of the selected communities. The children completed the German version of the CPQ11-14 questionnaire consisting of 50 questions about oral problems with 5 options for responding (the problem can occur: very often, often, sometimes, hardly often, never). Additionally, the children were interviewed for their overall well-being, which was measured using a 5-point scale ranging from 1 (excellent general health) to 5 (very bad general health). Statistical analysis (ANOVA) was performed to test the differences of CPQ11-14 summary score between the different groups using SPSS 16.0. Results: Following mean CPQ-G scores were evaluated within the different overall well-being groups: score 1 (excellent): 7.1 (± 7.5), score 2 (good): 9.0 (± 7.7), score 3 (moderate): 11.9 (± 10.1), score 4 (bad): 18.5 (± 15.6), score 5 (very bad): 20.5 (± 20.5). ANOVA revealed significant differences between the groups (p Keywords: oral health-related quality of life, Child Perceptions Questionnaire, validation