Maxillary sinus floor augmentation (SFA) is a procedure known for its long-term success and predictable outcomes. However, sinus membrane perforation remains the most common complication associated with this procedure. This systematic review aims to determine the presence of complications during maxillary SFA procedures using CAD/CAM surgical templates. An electronic search was carried out in MEDLINE (via PubMed), Web of Science, and Scopus. A descriptive analysis of the data was performed. Studies that performed lateral SFA were included, and the CAD/CAM surgical template design and the intraoperative complications were registered. A total of 13 studies (7 case reports, 4 case series, and 2 randomized clinical trials) and a total of 94 lateral SFA procedures (84 using CAD/CAM templates and 10 without templates) were included. Three of the 84 maxillary SFAprocedures using a CAD/CAM template presented intraoperative complications. Maxillary SFA performed using CAD/CAM surgical templates could be related to low rates of complications. However, due to the heterogeneity of the included articles, more standardized studies are needed to confirm these outcomes.