An example of a developmental dental anomaly is a higher than normal number of teeth. Supernumerary teeth may be of different varieties, including mesiodens, distomolar and paramolar. The term ‘mesiodens’ refers to a supernumerary tooth present in the maxillary midline between the central incisors. Dental anomalies have the highest priority of treatment among orthodontic problems. Early diagnosis and treatment may help to prevent complications and improve self-perception and social integration. The present case report demonstrates that a properly intercepted case of mesiodens can be successfully treated with clear aligners because the Invisalign First (Align Technology, San Jose, CA, USA) system has specific features that are suitable for growing patients. Invisalign First is a new system of clear aligners designed to address a broad range of malocclusions in younger patients, for example through management of shorter clinical crowns and erupting dentition and predictable dental arch expansion.