Self-adhesive resin cements have gained popularity over the past few years because of their improved physical properties as compared to conventional cements. New brands have simplified clinical handling, a wider range of applications and reduced pulp injury. Postoperative hypersensitivity and pulp injury was a problem in the past. The aim of this prospective controlled clinical study was to evaluate a new self-adhesive resin cement for postoperative sensitivity. Additionally, changes in cement colour, quality of the marginal seal, as well as the occurrence of decementations were registered. 16 patients received 43 full-coverage restorations on vital abutment teeth. The crowns were cemented with new self-adhesive resin cement. The teeth were inspected immediately after cementation, after 2 weeks (baseline) and after 6 months. Tooth sensitivity (abutment tooth and reference tooth) was examined with an ice spray test. After cementation postoperative hypersensitivity was diagnosed in 7% of the 43 vital abutment teeth. At baseline (after 2 weeks) the rate was reduced to 4.7%. Postoperative hypersensitivity was not reported after 6 months. The overall clinical experience proofed the cement to be an encouraging alternative to conventional cements with regard to postoperative sensitivity and ease of application. Keywords: postoperative sensitivity, self-adhesive cement, dental cements, luting of crowns