Objectives: The aim of the present study was to evaluate the influence of a commercially available home bleaching agent (Perfect Bleach 17%, Voco, Germany) on microtensile bond strength of four different dentin adhesives (Syntac and AdheSE, Vivadent, Liechtenstein; XP Bond, Dentsply DeTrey, Germany; Futurabond NR, Voco, Germany) in class V cavities in vitro. Methods: 120 freshly extracted third molars were included in this study. In all teeth cervical class V dentinal cavities were prepared also allowing the simulation of dentin perfusion. The specimens were randomly assigned to eight experimental groups of fifteen each: S: Syntac/ control; S17: Syntac/ Perfect Bleach; A: AdheSE/ control; A17: AdheSE/ Perfect Bleach; X: XP Bond/ control; X17: XP Bond/ Perfect Bleach; F: Futurabond NR/ control; F17: Futurabond NR/ Perfect Bleach. Bleaching was performed 8 hours at 36°C for 7 days. Microtensile bond strength of the above mentioned bonding agents was measured using an universal testing machine. Results: Statistical analysis showed a significant influence of the used dentin bonding agent and the bleaching agent on microtensile bond strength (p Keywords: bond strength, home bleaching, dentin adhesives