The case reported shows a 54-year-old Caucasian woman returning from a holiday travel to tropical Peru with an erythematous infraorbital swelling. Since initial therapeutic approaches with an antibiotic regimen proved inadequate ensuing sonographic examinations eventually diagnosed myasis. Myasis is an infectious disease which mainly occurs in tropical and subtropical regions of the world where the climate is hot and humid. It is characterized by infestation of human (or animal) tissue with fly larvae or dead larval tissue. The in our case causative insect Dermatobia hominis belongs to the class of two-winged flies (Diptera) and is native to Central and South America. The therapy consists of surgical removal of the larva in-toto. We propose contemporary screening for myasis in travelers to tropical regions with signs of soft tissue inflammation to impede unnecessary diagnostic delay. Keywords: Myasis, Dermatobia hominis, Travel medicine, Infraorbital skin