The treatment of teeth with severely calcified canals is a difficult procedure for clinicians. Procedural accidents such as drill path deviation or perforation of the root canal often occur. 3D-printed directional guides made using CBCT and CAD/CAM can help the clinician to accurately drill in the original root canal direction. Furthermore, chairside operating times and excessive loss of tooth structure are reduced, and the risk of perforation is avoided. The present case report describes two cases of calcified root canals with path deviations that were retreated utilizing a guided endodontic technique. Keywords: guided endodontics, calcified root canal, CAD/CAM, root canal retreatment