Introduction: Oral microorganisms can contribute to the pathogenesis of many diseases in the oral cavity such as caries, periodontitis, peri-implantitis and denture-related stomatitis. Yet, oral microorganisms may also have a considerable influence on the onset of systemic medical conditions such as lung or cardiovascular diseases. Microorganisms are organized in biofilms and they colonize teeth, mucosa, and dental restorations; the extent to which biofilms are accessible during self-performed oral hygiene varies widely. Discussion: The current demographic trends show that the population is getting older and that an increasing number of elderly and multimorbid patients require nursing care, most of whom already have and/or will receive removable dentures in the future. Impaired motor skills and cognitive abilities often lead to difficulties in self-performed oral hygiene, thus making these patients reliant on others for assistance. The regular accumulation of biofilm on removable dentures, which is not sufficiently removed, may trigger and foster the onset of oral and systemic diseases in immunologically compromised patients. Usually, removable dentures are fabricated from polymeric mate-rials and polymethylmethacrylate is the most frequently used material. In spite of this, many new materials are currently being introduced on the market which can be used to make removable dentures. The range of available materials has become increasingly broad and it includes materials based on polymethylmethacrylate as well as composite-based materials and polymeric materials with a distinct polymer chemistry. Relevant differences exist between the bioadhesion of materials that are processed using classical methods as compared to CAD/CAM-manufacturing. Conclusion: In this context, the current article aims to describe the impor-tance of biofilms on removable dentures, to outline relevant interactions of oral microorganisms with the surface of polymeric materials, and to present strategies for minimizing bioadhesion on removable dentures. Keywords: polymeric materials, CAD/CAM-manufacturing, biofilms, microorganisms, removable dentures