Purpose: This in-vitro study aims to investigate whether the wettability of two zirconia implant

disk surfaces is affected by glycine and erythritol air-polishing, using saline, bovine serum

albumin, bovine thrombin, and bovine artificial blood as the testing mediums. Materials and

Methods: Zirconia disks were provided by two implant companies: SDS. (Swiss Dental

Solutions, Plymouth, MA, USA) (n=6) and Patent. (Zircon Medical AG, Altendorf,

Switzerland) (n=6). Surface parameters (Sa, Sz, Sdr, Ssk, Sku, and Spd) were measured to

determine their initial surface roughness. Air-polishing was completed using glycine or erythritol

powders using the AIRFLOW. PERIO device (Manufactured by Electro Medical Systems

(EMS)). The wettability of the disk surfaces was evaluated by the contact angle analysis applied

on treated and untreated disks using four wetting solutions, saline, bovine serum albumin (BSA),

bovine thrombin, and bovine artificial blood. In total, 720 contact angle measurements were

completed with n=30 per group. Statistical analysis was performed using the one-way analysis of

variance and post-hoc Tukey HSD test. Results: The results indicate SDS. has a greater

wettability than Patent. before and after air-polishing. The wettability of surfaces treated with

glycine was hydrophobic in some cases. Erythritol increased the surface wettability of zirconia

disks compared to glycine. BSA and bovine artificial blood had lower contact angles than saline

and bovine thrombin for both untreated disks. Conclusions: The initial wettability of zirconia

disks differs between manufacturers, and air-polishing with erythritol powder increases the

wettability of zirconia implant disks for saline, bovine serum, bovine thrombin, and bovine

artificial blood.