This study aimed to clinically evaluate the efficacy of two different home whitening protocols and to

determine which is more effective: applying the whitening gel every 48 hours or every 72 hours for 6

weeks. The differences in terms of tooth sensitivity are also analyzed. A sample of 72 patients was

randomly divided into 3 groups of 24 (N=24). Group A: 16% carbamide peroxide applied every 48h

for 6 weeks. Group B: 16% carbamide peroxide applied every 72h for 6 weeks. Group C (control

group): a placebo gel without peroxide (glycerin gel) was applied every 48h for 6 weeks. To compare

the groups, color measurements were made using a spectrophotometer and ANOVA test and

Bonferroni test was used. The confidence level was set at 95% (p ≤ 0.05) and no statistically

significant differences between applying 16% carbamide peroxide every 48h or every 72h for 6 weeks

(p> 0.05) were found. The study concluded that carbamide peroxide 16% is equally effective applied

with both protocols, obtaining the same results.