This case report describes the successful treatment of an 11-year-old girl with skeletal Class II malocclusion, mandibular retrognathism and anterior crowding using clear aligners. The treatment strategy included extraction of the four first premolars to resolve dental crowding, the use of Class II elastics to achieve bite jumping and canine and molar Class I occlusion, and delicate vertical control to improve the patient’s lateral profile. After 4 years of treatment, all the treatment objectives, including dental alignment, mandibular repositioning and improvement of the lateral profile, were achieved successfully. The present case demonstrates the effectiveness of and advantages offered by clear aligners and Class II elastics as an alternative treatment option for adolescent patients with Class II malocclusion and severe crowding. Keywords: bite jumping, Class II malocclusion, growing patient, Invisalign, mandibular retrusion, premolar extraction