Zirconia (ZrO2) has today firmly established itself in crown and bridge prosthetics. In combination with modern, subtractive CAD/CAM procedures, it can be used in almost all restorative indications. The material itself has been significantly improved over the last two decades in terms of optical and mechanical properties and differentiated variations of zirconia are available for the respective indication. It appears obvious that not all zirconia is the same. The originally excellent mechanical properties in terms of flexural strength and fracture toughness have taken their toll in favor of optical improvements. Therefore, fractures can easily occur even with zirconia if marginal parameters are superimposed. This article is intended to raise awareness of the correct use of zirconia and the selection of suitable parameters and preparation designs.