This study evaluated the fracture loads of different threeunit fixed dental prostheses (FDPs) for temporary restorations. In total, three CAD/CAM materials (VITA CADTemp [CT], Telio CAD [TC], and ZENO ProFix [ZP]) and two chairside materials (Protemp 4 [PT], and Dentalon Plus [DP]) were used for the fabrication of the FDPs. Sixteen FDPs were fabricated from each material in an anatomical shape and stored in 0.9% NaCl solution at 37°C for 14 days. Thereafter, one half of the specimens from each group (n = 8) were additionally mechanically and thermally loaded (240,000 chewing cycles, 50 N, 5°/55°C, 2,100 thermal cycles). Fracture loads were measured and data analyzed using two- and one-way ANOVA, followed by Scheffé's post hoc test. ZP showed the highest mean fracture loads, regardless of the aging regime. Significantly lowest values were identified for DP and TC within the non-thermal loaded group, and for PT and CT within the thermal loaded group. No negative impact of aging regimes could be observed. Keywords: chewing simulation, fracture load, PMMA, polymeric CAD/CAM materials, temporary restorations