Vita Enamic is a durable hybrid ceramic that can be processed with efficient computer-aided design/computer-aided manufacturing (CAD/CAM) support. The porous sintered feldspar ceramic block that is infiltrated with polymer does not require a ceramic furnace after being ground out. Instead, it only needs to be finished and polished. This makes one-time chairside treatment possible. In addition to the well-known monochromatic Vita Enamic blocks, a multichromatic version with integrated shade gradient and a super-translucent version have been developed. The goal of this application study is to demonstrate these new indications with their material benefits in the anterior and posterior regions using four different case studies. Keywords: Computer-aided design/computer-aided manufacturing (CAD/CAM), hybrid ceramics, multi-chromaticity, super-translucence, Cerec