Purpose: To evaluate the mechanical and physical properties of experimental HEMA-containing and HEMA-free resin adhesives. Materials and Methods: Experimental HEMA-free adhesives containing alternative dimethacrylates (bis-EMA 10 [B10], bis-EMA 30 [B30], PEG 400 [P400], PEG 1000 [P1000], PEG 400 UDMA [UP400]) were formulated and compared with a HEMA-containing adhesive (control). The adhesives were characterized by rheological analysis, polymerization kinetics (PK), water sorption (WS), and solubility (SL) tests. Flexural strength (FS) and flexural modulus (E) tests were performed under dry or wet conditions (distilled water or 70% ethanol solution). One-way and two-way ANOVA as well as Tukey's test were used to evaluate differences between groups (p 0.05). Results: The control group showed the lowest viscosity and was the only one with a degree of conversion lower than 50%. The control and the P1000 adhesive showed the statistically significantly highest WS (p 0.05). The control and the UP400 adhesive showed the highest FS and E, and the dry-stored specimens showed more improved mechanical strength than did the wet-stored specimens (p 0.05). Conclusion: The physicomechanical properties of some of the HEMA-free adhesives were substantially improved when compared with those of the control, indicating that they could be potential monomers for the development of HEMA-free adhesive systems. Keywords: dental adhesives, HEMA, hydrophilicity, cross linking, FTIR, mechanical properties