Purpose: To evaluate the microtensile bond strength of indirect resin composite inlays to dentin using two cementation strategies, before and after mechanical aging. Materials and Methods: Standardized inlay cavities (bucco-lingual width: 3 mm; depth: 4 mm) were prepared in 32 human premolars. The teeth were embedded in self-curing acrylic resin up to 3 mm from the cementoenamel junction, impressions were made using a polyvinyl siloxane material, master dies were obtained using type 4 stone, and inlay composite resin restorations were fabricated (Sinfony, 3M ESPE). The teeth were randomly allocated into 4 groups according to the cementation strategy (conventional [C] and simplified [S]) and aging (mechanical cycling [MC] and not aged): C[G1]: Adper SingleBond + RelyX ARC without aging; CMC[G2]: conventional cementation + mechanical cycling (106 cycles, 88 N, 4 Hz, ± 37°C); S[G3]: self-adhesive resin cement (RelyX U-100) without aging; SMC[G4] self-adhesive cementation + mechanical cycling. Intaglio surfaces of composite inlays were treated by tribochemical silica coating in G1 and G2, while G3 and G4 received no surface treatment. Non-aged specimens were stored in a moist environment at ca 37°C for the same period as MC (3 days). Non-trimmed beam specimens (bonding area = 1 mm2) were produced by serial cutting, and microtensile testing was performed (0.5 mm/min). Results: Two-way ANOVA showed that the microtensile bond strength was affected only by cementation strategy (p 0.0001). Tukey's test showed that groups G1 (35.1 ± 9.1) and G2 (32.7 ± 10.7) presented significantly higher bond strength values than G3 (8.7 ± 6.3) and G4 (5.2 ± 4.6). Conclusion: The use of a conventional adhesive technique and tribochemical silica coating resulted in higher μTBS than the one-step simplified cementation, even after mechanical cycling. Keywords: adhesion, cementation, indirect resin, mechanical cycling, microtensile bond strength