Purpose: To evaluate the effect of different mechanical pre-treatments on the bond durability to dental zirconia. Materials and Methods: Fully sintered IPS e.max ZirCAD (Ivoclar Vivadent) blocks were randomly assigned to one of 4 groups: (1) kept as-sintered (control), (2) sandblasted with 50-μm Al2O3 (Danville), or tribochemically silica sandblasted using (3) CoJet (3M ESPE) and (4) SilJet (Danville). The zirconia specimens were additionally pre-treated chemically using a 10-MDP/silane ceramic primer (Clearfil Ceramic Primer, Kuraray Noritake). Two identically pre-treated zirconia blocks were bonded together using resin-composite cement (RelyX Ultimate, 3M ESPE). The specimens were trimmed at the interface to a cylindrical hourglass shape and stored in distilled water (7 days, 37°C), after which they were randomly tested as is or subjected to additional mechanical aging involving cyclic tensile stress (10 N, 10 Hz, 10,000 cycles). Subsequently, the microtensile bond strength was determined and SEM fractographic analysis performed. Results: Weibull analysis revealed the highest Weibull scale and shape parameters when zirconia was tribochemically silica sandblasted using either CoJet or SilJet. The Weibull shape parameter of Al2O3-sandblasted zirconia was significantly reduced upon mechanical aging, but not when zirconia was tribochemically silica sandblasted. Conclusion: The mechanical surface pre-treatment of zirconia using tribochemical silica sandblasting (CoJet, SilJet) resulted in the most favorable bond durability of a resin-composite cement (RelyX Ultimate) to dental zirconia before and after aging. Keywords: zirconia, bond strength, tribochemical silica sandblasting, silane, composite cement, aging