Purpose: To evaluate the light transmission characteristics of different types, shades, and thicknesses of novel CAD/CAM materials and their effect on the degree of conversion (DC) of a dual-curing resin cement. Materials and Methods: Square specimens (12 × 12 mm2) of three CAD/CAM materials - GC Cerasmart, Lava Ultimate, Vita Enamic - of different thicknesses (1.00, 1.50, and 2.00 mm, n = 5 per thickness) were irradiated with an LED unit. The amount of transmitted light was quantified. Thereafter, the DC% of the dual-curing resin cement (RelyX Ultimate) was recorded after 15 min using Fourier transform infrared spectroscopy. Statistical analysis was performed using two-way ANOVA followed by the Tukey's HSD post-hoc test at a significance level of p 0.05. Regression analysis was performed to investigate the correlation between the DC and radiant energy, and the DC and thickness. Results: Although the type and shade of CAD/CAM material significantly affect transmitted light irradiation (p 0.0001), degrees of conversion are similar when the CAD/CAM material or material shade were taken into consideration (p > 0.05). Conversely, material thickness significantly affected light transmission (p 0.0001) and DC (p 0.0001). Multiple effects of material, shade, and thickness did not significantly affect the evaluated parameters (p = 0.638 for light irradiation; p = 0.637 for DC). Linear regression analysis showed a correlation between delivered energy and DC% results of the Vita Enamic (R² = 0.4169, p 0.0001). Conclusion: Reduced light transmission in 2-mm-thick specimens of all CAD/CAM materials indicates that proper curing of the cement beneath CAD/CAM materials should be ensured. Keywords: hybrid nanoceramic, polymer infiltrated ceramic, resin nanoceramic, light transmission, degree of conversion