Purpose: To investigate the effect of a universal adhesive on the bond strength of composite cements to a polymer-infiltrated ceramic network. Materials and Methods: Shear bond strength to a polymer-infiltrated ceramic network (Vita Enamic) and to its polymer and ceramic components was assessed on polished surfaces using either a conventional dual-curing resin (RelyX Ultimate) or self-adhesive composite cement (RelyX Unicem 2 Automix). Substrate surfaces were either not pretreated or a silane coupling agent (Vitasil), a universal adhesive (Scotchbond Universal Adhesive), or both were applied. Further, the shear bond strength to polymer-infiltrated ceramic network was evaluated after etching with 5% hydrofluoric acid (Vita Ceramics Etch) of 0, 15, 30, 60 or 120 s without or with application of silane, universal adhesive, or both (n = 10). Statistical analysis was performed using the Kruskal-Wallis test (p 0.05) followed by post-hoc comparisons with Bonferroni correction. Results: No bond (0 MPa) was formed to the polished polymer-infiltrated ceramic network or to its components for either cement. Application of silane resulted in low mean bond strengths (4 to 5 MPa) to the ceramic. The universal adhesive bonded mainly to the polymer part of the polymer-infiltrated ceramic network. The best bonding performance for both cements was achieved when silane and universal adhesive were applied on the polymer-infiltrated ceramic network. Etching for 30 s or 60 s resulted in the highest mean shear bond strengths for all pretreatment groups (p 0.05). Conclusion: The best bonding performance of the self-adhesive dual-curing composite cement RelyX Unicem 2 Automix was found on the HF-etched polymer-infiltrated ceramic network. The conventional dual-curing composite cement RelyX Ultimate with Scotchbond Universal Adhesive may bond chemically to the polymer part of the polymer-infiltrated ceramic network. To achieve the highest bond strengths for both cements, the polymer-infiltrated ceramic network should be etched for 30 to 60 s, followed by the application of silane and universal adhesive. Keywords: shear bond strength, polymer-infiltrated ceramic, universal adhesive, silane, hydrofluoric acid etching