Purpose: To evaluate the effect of surface treatments and aging on the bond strength of composite cement to a novel CAD/CAM nanohybrid composite. Materials and Methods: Microtensile bond strength (µTBS) of a dual-curing composite cement (Bifix QM; BQ) to three CAD/CAM restorative materials (Grandio [GR], Vita Enamic [VE], and Lava Ultimate [LU]) was evaluated after different surface treatments. The surfaces of specimens received the following treatments: control (no treatment), sandblasting (SB), SB + silane (Ceramic Bond; CB), hydrofluoric acid (HF), HF + CB, TiF4 2 wt/v%, TiF4 2 wt/v% + CB, TiF4 4 wt/v%, and TiF4 4 wt/v% + CB. Half of the specimens in each group were aged. Surface topography and surface roughness were evaluated. Statistical analysis was conducted using ANOVA and Tukey's test. The Weibull analysis was conducted on µTBS data of aged groups. Results: The µTBS was significantly affected by the type of CAD/CAM material, type of treatment, and aging (p 0.001). Silane application significantly improved the µTBS (p 0.05). The µTBS decreased significantly with aging (5000 thermocycles) (p 0.05). BQ cement resulted in the highest μTBS to GR treated with TiF4 2% wt/v + CB compared to the other groups (p 0.05). Aged GR/BQ treated with TiF4 2% wt/v + CB had the highest predicted µTBS (19 MPa). Conclusion: TiF4 2% wt/v followed by silane application enhanced the adhesion of GR/BQ and LU/BQ systems. On the other hand, HF surface treatment followed by silane application improved the adhesion of the VE/BQ system. Keywords: bond strength, composite cement, nanohybrid CAD/CAM, polymer-infiltrated ceramic, resin nanoceramic, surface roughness, surface treatments