The concept of tooth preparation for ceramic veneers remains controversial regarding whether the use of a palatal chamfer would affect the longevity of restorations. This study aimed to evaluate the load-fatigue testing of ceramic veneers using two different preparation designs-an incisal shoulder finish line with or without a palatal chamfer. A pressable ceramic veneer was bonded to the prepared maxillary central incisor using resin cement. The number of cycles until fatigue failure for each tooth-veneer specimen was recorded. Results revealed that using a palatal chamfer margin design significantly increased the fatigue failure cycle count.