Purpose: Ceramic materials, first introduced in restorative dentistry in the late 18th century, offer a wide range of possibilities and exhibit esthetic properties. The last systematic reviews on the subject of ceramic inlays were published in 2003. All articles published up to 2001 were surveyed regarding the longevity, esthetic qualities, and postoperative discomfort associated with the use of ceramic inlays compared to other restorative materials. The present review aimed to establish the current state of the art. Materials and Methods: Using methods identical to those of previous reviews, the literature from 2001 up to and including 2009 was assessed. The scientific and methodologic qualities of all articles describing the use of ceramic inlays were established. Articles comparing the results of ceramic inlays to other types of inlays were then used to answer the hypotheses that there were no differences in longevity, postoperative sensitivity, or color match. Results: Three articles comparing the results of ceramic to other materials were analyzed further. No new reliable evidence was found to update the answer to the hypothesis that there was no difference in longevity, at least in the first year postoperative. The evidence found regarding postoperative discomfort backs the previous conclusion that there was no difference. New evidence found on color matching suggests that there is no significant difference in color match over assessment periods of up to 57 months. Conclusion: Current ceramic materials in inlay restorations seem to perform as well as other restorative options for selected properties during the first years after placement.