Purpose: To evaluate the outcome of maxillary implant overdenture treatment in a selected patient sample. Materials and Methods: Eighteen out of a total of 26 patients who were prescribed overdentures supported by two to six implants each attended a follow-up clinical assessment. Evaluative criteria included oral health- related quality of life records using the OHIP-14 questionnaire. Results: Good stability and retention were observed, and mechanical failure items were recorded in eight patients. No significant differences in OHIP-14 scores were found between patients treated with two to three implants and patients treated with five to six implants, or between groups treated with a denture with palatal or horseshoe design coverage. Conclusion: Maxillary implant overdenture treatment was assessed as a viable treatment option for the selected patient sample, even when only two supporting implants were prescribed.