Purpose: The aim of this study was to determine endodontic treatment needs and types of endodontic disease following fixed prosthodontic treatment 24 hours after tooth preparation, 1 week after tooth preparation, 1 month after placement, and 6 months after placement. Materials and Methods: Study groups consisted of patients who attended a university dental hospital department of prosthodontics for fixed prosthodontic treatment from January 2011 to December 2013. All teeth were clinically and radiographically evaluated according to American Association of Endodontists evaluation criteria before preparation. Metal-ceramic fixed partial dentures were placed for all patients. A total of 1,633 abutment teeth were prepared with 1,100 pontics in 524 patients (214 female and 310 male). Participant age, sex, and tooth number were recorded. Endodontic treatment follow-up was scheduled for 24 hours after tooth preparation, 1 week after preparation, 1 month after placement, and 6 months after placement, and all teeth were evaluated after placement of FPDs according to a modified criteria. Results: 2,733 retainers were placed with 624 FPDs. Of the FPDs, 332 (53%) were placed in the posterior and 196 (31.5%) in the anterior region. The remaining 96 FPDs (15.5%) were placed anteroposterior. The abutment/pontic ratio was 1.44:1. The number of retainers per FPD was 4.37. Of 1,633 abutment teeth, 103 were endodontically treated after placement of FPDs. Most observed endodontic disease was symptomatic irreversible pulpitis. There were statistically significant differences in terms of teeth regions (P .001). When follow-up times of 24 hours, 1 week, 1 month, and 6 months were evaluated, there was no statistically significant difference among all teeth groups (P > .05). Conclusion: A total of 2,733 retainers on 624 FPDs were evaluated over 6 months, and the mean endodontic treatment need ratio was 6.3%.