This case history report describes the fabrication of a mandibular prosthesis for an edentulous patient with four implants. Impressions were made with a photogrammetry system, and the framework was manufactured using cobalt-chromium laser sintering, later milled at the implant connection level, and then coated with a composite resin. The described protocol suggests that the employed manufacturing technologies readily lend themselves to routine management of the edentulous mandible, although further research and long-term clinical data are clearly needed.