Ameloblastomas are remarkable among odontogenic tumours because of their particular clinical and histological behaviours, including infiltrative potential, high recurrence rate and capacity to metastasise. Knowledge of the mechanism for invasion is essential for selecting the most appropriate therapeutic approach and anticipating a prognosis for each case. In this paper, some up-to-date frontier research on the different molecular biological aspects related to the invasiveness of ameloblastoma is reviewed to elucidate several points that still remain unclear. Keywords: ameloblastoma, invasiveness, molecular mechanism