Guided bone regeneration is a well- established technique used for augmentation of deficient alveolar ridges. There is much evidence in the literature to support the success of this procedure. Multiple techniques have been introduced using various types of membranes and bone grafting materials. However, efficacious regeneration requires both a high level of technical skills and a thorough understanding of major biological principles. This case report is presented to illustrate a reliable approach to successful management of two different alveolar defects.