In this article, the interdisciplinary management of an isolated-type recession defect in a severely compromised mandibular incisor of a young post-orthodontic patient is described. The prognosis of root coverage surgery was very questionable and unpredictable due to the severe root malposition (III Miller class gingival recession). The treatment plan consisted of: (1) interproximal enamel reduction to gain space within the dental arch, (2) orthodontic repositioning of the root of the affected tooth within the alveolar bone and (3) root coverage mucogingival surgery. Clinical re-evaluation 7 months after fixed orthodontic treatment revealed major improvements in the root coverage prognosis due to the resolution of root malposition and de novo formation of keratinized tissue apical to the root exposure (I Miller class gingival recession). A subepithelial connective tissue graft was performed as a root coverage surgical procedure. Clinical examination 1 year after surgery revealed complete root coverage, good color blending with adjacent soft tissue and an increase in facial gingival thickness. Successful periodontal and esthetic outcomes can be accomplished after the combined orthodontic-periodontal treatment of a severely mucogingivally compromised tooth.