This case report describes the treatment of a 55-year-old man who presented with a missing maxillary first molar and mesially inclined neighboring second molar with a severe circumferential bone defect. After bone regeneration therapy with bone grafting, the second molar was uprighted orthodontically to improve the inclination and crown-to-root ratio. These treatments minimized the bone defect and developed a suitable site for an implant in the first molar position. An interdisciplinary approach using periodontal, orthodontic, and prosthodontic treatments can create a more predictable and maintainable situation.