DOI: 10.11607/prd.1723, PubMed ID (PMID): 25411741Pages 848-855, Language: EnglishTovar, Nick / Jimbo, Ryo / Marin, Charles / Witek, Lukasz / Suzuki, Marcelo / Bonfante, Estevam A. / Coelho, Paulo G.This study investigated whether the use of a dual-layer polytetrafluoroethylene (PTFE)/porcine-derived bioresorbable pericardium membrane enhances the osseointegration around implants compared to a single-layer porcine-derived bioresorbable pericardium membrane and a no-membrane control group. Endosseous implants were placed in the fresh extraction sockets of beagles. At 6 weeks, bone loss and apical soft tissue migration occurred in the control group, whereas bone successfully formed to the neck of the implant for the single-layer porcine-derived bioresorbable pericardium membrane group. The dual-layer PTFE/ porcine-derived bioresorbable pericardium membrane showed bone growth coronal to the neck of the implant. Bone-to-implant contact and buccal bone loss were respectively higher and lower relative to the single-layer but not statistically different.