Purpose: To present a case report of autogenous transplant of two impacted mandibular canines. Materials and methods: A 12-year-old girl, with vestibular impaction of mandibular left and right canines had them extracted and transplanted in the anatomically corrected sites, after an unsuccessful orthodontic treatment including surgical exposure. Results: After 2 years the teeth are stable and their vitality is maintained. Conclusions: In this case the transplantation of the mandibular canines was successful and maintained the vitality of the transplanted teeth for at least 2 years. By preserving the periodontal ligament is it possible to re-establish a functional tooth unit, which allows a physiologic growth of the jaws. Keywords: autogenous transplant, case report, impacted canines Conflict-of-interest statement: The authors declare no conflicts of interest.