The liposarcoma of the tongue, an extremely rare tumor is reported in the literature in only 11 cases. None of these cases described a multilocular presentation. Adults between the ages 50 and 70, in the majority men, are primarily afflicted. 20% of all soft tissue tumors are liposarcoma, and 4% occur in the head and neck area. Liposarcoma exhibits a predilection for the trunk and the lower extremities. Most of the liposarcoma tumors in the head and neck region have been located in the cheek and the floor of mouth, however seldom in larynx, lips, maxilla or soft palate.A 40-year-old male reported over 3 years progredient growing tumor in the anterior part of the tongue. Speech was unrestricted and very important for the field worker. Magnet resonance imaging showed 7 tumors with a size to 3x2x1 cm and the biopsy showed a well-differentiated myxoid liposarcoma. Furthermore a local resection of others tumors was done without functional deficits. Radiation therapy may be beneficial, but on account of a low expansion of liposarcoma and the location of tumor we did not apply adjuvant radiotherapy. All 6 to 8 weeks control was made by sonographic or magnet resonance imaging. The patient is without recidivism. Keywords: liposarcoma, tongue, multilocular, myxoid, well-differentiate