The aim of the present investigation was to evaluate tensile bond strength of three dentin adhesive systems (Excite, Clearfil New Bond, Etch & Prime 3.0) and two cyanoacrylate adhesives (Cyano Veneer, Histoacryl) to animal bone in vitro. Therefore, five mandibles of freshly sacrificed pigs were included. From each mandible ten specimens were prepared using rotating burs under constant water cooling. Bone specimens (diameter 9 mm) with a total thickness of 4 mm (± 0.5 mm) and a cortical layer of 1.5 mm (± 0.2 mm) were obtained under standardized conditions. Each ten specimens were assigned to five experimental groups. Tensile bond strength of the above mentioned adhesive agents was measured 15 minutes after application and light curing of the composite material (Tetric Ceram, colour A2) using an universal testing machine. Following tensile bond strengths were evaluated (mean value and standard deviation, printed in MPa): Excite: 2.96 (± 1.34); Clearfil New Bond: 8.00 (± 1.36); Etch & Prime 3.0: 4.05 (± 1.53); Cyano Veneer: 4.56 (± 0.76); Histoacryl: 5.22 (± 2.01). Statistical analysis showed a significant influence of the used adhesive system on tensile bond strength (p Keywords: bone, dentin bonding agent, cyanoacrylate, bond strength, composite material