Introduction: After completion of chemotherapy, the invent of prerequisites allow fabrication of denture and rehabilitation of occlusion and oro-facial system's function. Case report: The patient NL, aged 64 yrs.,was inspected at the University Clinic of dental prosthetic in Belgrade. She submitted the confirmation on completion of chemotherapy, after tumorous tissue removal. The fabrication of partial casted denture was indicated in her upper jaw. The denture was initially designed respecting remaining teeth in the upper jaw, with particularly designed base of the denture respecting shapes and forms of palatal tissues. Mastication, speech and swallowing were rehabilitated in this patient. There were not pathologic changes in her mouth, at recall. Conclusion: Partial casted denture for upper jaw, when designed in accordance with shape of supporting tissues after chemotherapy, is successful mode of treatment of partially edentulous patients after surgery and removal of tumor. Keywords: maxilla, denture, cast denture, cancer