Objective: To update the scientific evidence relating to the efficacy of clear aligner treatment (CAT) in controlling orthodontic tooth movement (OTM). Materials and methods: International medical databases were searched to identify all peer-reviewed papers potentially relevant to the review. The quality of evidence was ranked using the Swedish Council on Technology Assessment in Health Care Tool criteria. Results: Twenty relevant articles were selected and the quality of evidence was high for three studies, moderate for 12 studies and low for five studies. Mesio-distal tooth movement revealed the highest predictability, with a molar distalization up to 2.5 mm and space closure of 7 mm performed with good control. Arch expansion is predictable up to 2 mm on molars. Improvements in Little's and PAR Index were reported in mild to severe malocclusions. Conclusion: The overall quality of available evidence was of moderate/high level. CAT aligns and levels the arches even in severe cases, with efficient control of incisors inclination. Arch expansion and tooth bodily movement are efficiently achievable movements with CAT. Keywords: clear aligners, Invisalign, invisible orthodontics, orthodontics